ceesdekker.net Fundamentals Explained

ceesdekker.net Fundamentals Explained

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Nanotechnology gives A variety of prospects to add to biology. In this article I'll existing illustrations where nanofabrication – the ability to make confined structures with dimensions at will – is utilized to examine the biophysics of single molecules and cells. I'll present some examples from our lab:

Reconstitution of ultrawide DNA origami pores in liposomes for transmembrane transport of macromolecules

, Groningen scientists existing the results of their efforts to create labs a lot more sustainable and provide techniques for other labs. 

Nanofabrication of electrodes with sub-five nm spacing for transport experiments on solitary molecules and metallic clusters

2015, discovery that condensin is actually a extremely adaptable protein composition; and 1st detection of DNA knots utilizing nanopores

Example (three) of bending configurations in 3D simulations of DNA rods on nanopores. A part of the membrane is shown in gray, the rim in the pore is highlighted in pink, and also a 3D rendering in the motion with the DNA rod is displayed.

Since 2000 he moved to one-molecule biophysics and nanobiology, with investigation from DNA supercoiling scientific studies of nucleosomes and DNA restore proteins to DNA translocation by means of nanopores. Lately his research has centered on learning mobile division with microorganisms on chip, although his ultimate desire is inside the direction of knowing artificial cells.

2000, discovery that nanotubes can carry incredible big ceesdekker.net recent densities; fixed the controversial concern of Digital transportation via DNA molecules by measurements of insulating habits at The one molecule level; and demonstration of an AFM strategy for one-molecule manipulation of nanotubes

This "Cited by" depend includes citations to the following content articles in Scholar. The ones marked * could possibly be unique from the article within the profile.

There was 1 issue even though — we did not observe any measurable electrical conduction from The only polymer molecules. We concluded that at The only-molecule degree, conducting polymers have been in fact not these good conductors, which was alternatively disappointing. We So broadened our view to test to uncover extra promising molecules.

An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes

1999, very first measurement of your wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof to get a new Luttinger description of interacting electrons in nanotubes

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It had been an exceedingly fascinating time, for the duration of which I been given lots of assist from Delft College of Technology, in which I used to be a professor at enough time, And that i started numerous collaborations with molecular biologists. That aided me study a lot.’